You can uninstall HTC Sync Manager by following steps below:
For Windows XP user, please select Control Panel from the Start, and select Add/Remove Programs icon when a new window is prompted. Click HTC Sync Manager then select Change/Remove button. The HTC Sync Manager will be uninstalled from your computer.
For Windows 7 user, please select My Computer from the Start, and select Uninstall or change a program button when a new window is prompted. Right click HTC Sync Manager then click Uninstall. HTC Sync Manager will be uninstalled from your computer.